Monday, January 8, 2024 at 12:00 pm (please email qcri@queensu.ca for location)
Amir Horowitz, PhD
Associate Professor, Depts. of Immunology & Immunotherapy, Oncological Sciences
Lipschultz Precision Immunology Institute, Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai, New York
@AmirHorowitz
“Tumor HLA-E expression and CMV infection modulate NK cell activity in human bladder cancer”
Dr. Horowitz's research focuses on human NK cells and CD8 T cells and their functional roles in microbial infections and cancers, where his lab utilizes cutting-edge single-cell resolution analyses to understand pathways that can be perturbed for immunotherapeutic benefit. During this seminar, Dr. Horowitz will discuss the HLA-E/NKG2A inhibitory axis in NMIBC as a driver of resistance to BCG therapy and then how cytomegalovirus infection perturbs this axis through promoting expansion of adaptive NK cells expressing the activating HLA-E receptor, NKG2C resulting in protection from and control of tumor recurrence.
Host: Dr. Madhuri Koti
To see more seminars of the Queen’s Cancer Research Institute, please visit our website at: https://qcri.queensu.ca/about-us/seminar-series