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Tuesday, December 19th at 1:30pm (Dr. Sean Egan)</span> </h1> <span property="schema:name" content="a QCRI SPECIAL SEMINAR! Tuesday, December 19th at 1:30pm (Dr. Sean Egan)" class="rdf-meta hidden"></span> <span property="schema:interactionCount" content="UserComments:0" class="rdf-meta hidden"></span> <div class="post-meta"> <span class="post-categories"> <div class="field field--name-field-post-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/reseach-news" hreflang="en">Research news</a></div> </div> </span> | <span class="post-created"> 4 December 2023 </span> </div> </div> <div class="node__meta hidden"> <article typeof="schema:Person" about="/user/87" class="profile"> </article> <span> Submitted by <span rel="schema:author" class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/user/87" typeof="schema:Person" property="schema:name" datatype="">scriweb</span></span> on 4 December 2023 </span> <span property="schema:dateCreated" content="2023-12-04T19:44:06+00:00" class="rdf-meta hidden"></span> </div> <div class="node__content clearfix"> <div property="schema:text" class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><br><br> <strong>Tuesday, December 19, 2023<br><br> 1:30 pm</strong><br><br> For location, please email <a href="mailto:qcri@queensu.ca">qcri@queensu.ca</a><br><br> <br><br> <strong>Sean Egan, PhD</strong><br><br> Senior Scientist, Cell Biology, The Hospital for Sick Children<br><br> Professor, Dept. of Molecular Genetics, University of Toronto<br><br> <br><br> Talk Title: <strong><em>Using the mouse to study breast cancer - CNA and an endogenous mutagen</em></strong><br><br> <br><br> <span><span><span><span>Bio</span></span><span><span>:</span></span> <span><span>The Egan Lab develops immune-competent mouse models for mammary cancer as a means to probe genetic mechanisms responsible for tumor progression and metastasis, and also as a platform for the development of rational combination therapy which includes an immune-therapy component. Models have been developed or a number of common genetic alterations associated with human breast cancer including commonly mutated genes such as PIK3CA, as well as chromosome arm losses. More recently, these models are being used to define oncogene-specific networks of mutations that promote tumor progression and metastasis.</span></span></span></span></p> <p>Host: Andrew Craig, PhD</p> </div> </div> <div id="node-single-comment"> </div> </div> </article> <!-- End Display article for detail page --> </div> </div> </div> </div> </div> </div> <!-- Sidebar Left --> <!-- End Sidebar Left --> <!-- Sidebar Right --> <div class="col-lg-4 col-md-4 col-sm-12 col-xs-12 sidebar sidebar-right theiaStickySidebar"> <div class="sidebar-inner"> <div class="region region-sidebar-right"> <div id="block-gavias-financial-subscribeandtostayinformedaboutcancerresearch" class="block block-block-content block-block-content3a677b87-9495-4373-9021-c3f9d837e48d no-title"> <div class="content block-content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div id="mc_embed_shell"> <link href="//cdn-images.mailchimp.com/embedcode/classic-061523.css" rel="stylesheet" type="text/css"> <style type="text/css"> #mc_embed_signup{background:#fff; false;clear:left; font:14px Helvetica,Arial,sans-serif; width: 100%;font-family: "Open Sans" !important; background-color: #f6f6f6 !important; padding: 1px 0; } #mc_embed_signup h2{font-weight: 400;} #mc_embed_signup .button{background-color:#002452;} /* Add your own Mailchimp form style overrides in your site stylesheet or in this style block. 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