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Isabelle Grenier-Pleau, PhD candidate - Nov. 21, 2023 at 3:30 pm! QCRI 100/101 Conference Rooms </li> <li></li> </ol> </nav> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div role="main" class="main main-page"> <div class="clearfix"></div> <div class="clearfix"></div> <div class="clearfix"></div> <div id="content" class="content content-full"> <div class="container"> <div class="content-main-inner"> <div class="row"> <div id="page-main-content" class="main-content col-xs-12 col-md-8 sb-r "> <div class="main-content-inner"> <div class="content-main"> <div class="region region-content"> <div id="block-gavias-financial-content" class="block block-system block-system-main-block no-title"> <div class="content block-content"> <!-- Start Display article for teaser page --> <!-- Start Display article for detail page --> <article data-history-node-id="821" about="/news/research-news/qcri-seminar-isabelle-grenier-pleau-phd-candidate-nov-21-2023-330-pm-qcri-100101" typeof="schema:Article" class="node node-detail node--type-article node--promoted node--view-mode-full clearfix"> <div class="post-block"> <div class="post-thumbnail post-standard"> <div class="field field--name-field-image field--type-image field--label-hidden field__item"> <div class="item"> <img property="schema:image" loading="lazy" src="/sites/scri/files/articles/Grenier-Pleau_Isabelle.jpg" alt="November Seminar" typeof="foaf:Image" /> </div> </div> </div> <div class="post-content"> <h1 class="post-title"><span property="schema:name" class="field field--name-title field--type-string field--label-hidden">QCRI SEMINAR !! Isabelle Grenier-Pleau, PhD candidate - Nov. 21, 2023 at 3:30 pm! QCRI 100/101 Conference Rooms</span> </h1> <span property="schema:name" content="QCRI SEMINAR !! Isabelle Grenier-Pleau, PhD candidate - Nov. 21, 2023 at 3:30 pm! QCRI 100/101 Conference Rooms" class="rdf-meta hidden"></span> <span property="schema:interactionCount" content="UserComments:0" class="rdf-meta hidden"></span> <div class="post-meta"> <span class="post-categories"> <div class="field field--name-field-post-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/reseach-news" hreflang="en">Research news</a></div> </div> </span> | <span class="post-created"> 1 November 2023 </span> </div> </div> <div class="node__meta hidden"> <article typeof="schema:Person" about="/user/87" class="profile"> </article> <span> Submitted by <span rel="schema:author" class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/user/87" typeof="schema:Person" property="schema:name" datatype="">scriweb</span></span> on 1 November 2023 </span> <span property="schema:dateCreated" content="2023-11-01T12:38:37+00:00" class="rdf-meta hidden"></span> </div> <div class="node__content clearfix"> <div property="schema:text" class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Presenting next in our monthly seminar series is Isabelle Grenier-Pleau! PhD candidate in Dr. Abraham's lab.<br><br> <br><br> <strong>Tuesday, November 21, 2023 at 3:30 pm in QCRI conference rooms 100/101 (10 Stuart St.)</strong></p> <p><span><span><span lang="EN-CA"><span>“</span></span><span><span><span>EXTRACELLULAR VESICLES VARY WITHIN THE HUMAN HEMATOPOIETIC SYSTEM AND DIFFERENTIALLY INFLUENCE HEMATOPOIETIC STEM AND PROGENITOR CELLS</span> “</span></span></span></span></p> <p><span><span><span><span>Summary: Hematopoietic stem cells (HSC) are a rare population characterized by their unique ability to self-renew and differentiate into all lineage blood cells. HSCs reside in the bone marrow microenvironment, which is known to regulate the HSCs through the orchestration of a multitude of factors. Extracellular vesicles (EVs) are a heterogeneous group of nanoparticles delimited by a lipid bilayer and are believed to be released by all eukaryotic cells, including cells that comprise the bone marrow niche. EVs can transport biological cargo between cells as a form of intracellular communication, with the potential to induce functional changes in recipient cells. This project investigates whether EVs from distinct hematopoietic niches, namely peripheral blood plasma, bone marrow, and trabecular bone, play differing roles in regulating HSC quiescence, differentiation, and self-renewal. Understanding the interaction between HSCs and their microenvironment may aid in the development of regenerative medicine therapies for the treatment of hematopoietic diseases.</span></span></span></span></p> <p><span><span><strong><span><span>Host</span></span></strong><strong><span><span>: Madhuri Koti, DVM, MVSc, PhD</span></span></strong></span></span></p> </div> </div> <div id="node-single-comment"> </div> </div> </article> <!-- End Display article for detail page --> </div> </div> </div> </div> </div> </div> <!-- Sidebar Left --> <!-- End Sidebar Left --> <!-- Sidebar Right --> <div class="col-lg-4 col-md-4 col-sm-12 col-xs-12 sidebar sidebar-right theiaStickySidebar"> <div class="sidebar-inner"> <div class="region region-sidebar-right"> <div id="block-gavias-financial-subscribeandtostayinformedaboutcancerresearch" class="block block-block-content block-block-content3a677b87-9495-4373-9021-c3f9d837e48d no-title"> <div class="content block-content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div id="mc_embed_shell"> <link href="//cdn-images.mailchimp.com/embedcode/classic-061523.css" rel="stylesheet" type="text/css"> <style type="text/css"> #mc_embed_signup{background:#fff; false;clear:left; font:14px Helvetica,Arial,sans-serif; width: 100%;font-family: "Open Sans" !important; background-color: #f6f6f6 !important; padding: 1px 0; } #mc_embed_signup h2{font-weight: 400;} #mc_embed_signup .button{background-color:#002452;} /* Add your own Mailchimp form style overrides in your site stylesheet or in this style block. 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